← Issue №14/ week of Oct 4, 2026/Colorectal

Clinical characteristics and outcomes of bacterial and viral gastrointestinal infection by pathogen: a large-scale observational study in United States.

From GI Signals issue №14: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Colorectal retrospective · n=24,473 · Sep 30, 2026 · J Gastroenterology · IF 5.7

Clinical characteristics and outcomes of bacterial and viral gastrointestinal infection by pathogen: a large-scale observational study in United States.

Epidemiologyepidemiologypediatric
Clinical takeawayNo clinical action yet: this is an epidemiological study identifying pathogen-specific outcomes, which may inform future preventive or therapeutic strategies.
What it foundNorovirus had the highest all-cause 30-day mortality rate (1.7%) among viral pathogens, compared to 0.4% for rotavirus, 0.9% for adenovirus, 0.5% for astrovirus, and 0.5% for sapovirus.
ContextThis study confirms that severe outcomes from GI infections vary by pathogen, with norovirus posing higher mortality risk, particularly in the elderly and children under 5.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Kitano T … Yoshida S · Journal of Gastroenterology · IF 5.7 · PubMed ↗Permalink
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