← Issue №14/ week of Oct 4, 2026/Hepatology

Liver Transplantation Versus Resection for Single-Nodule Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

From GI Signals issue №14: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Hepatology meta analysis · n=5,094 · Sep 30, 2026 · J Hepatobil Pancreat Sci · IF 3.8

Liver Transplantation Versus Resection for Single-Nodule Hepatocellular Carcinoma: A Systematic Review and Meta-Analysis.

New evidencehepatocellular carcinomaliver transplantsystematic reviewmeta-analysis
Clinical takeawayConsider LT over LR for single-nodule HCC in eligible adult patients, particularly for long-term oncological benefit, but weigh baseline differences and the observational nature of the evidence.
What it foundLiver transplantation (LT) showed higher overall survival (OS) at 3, 5, and 10 years and superior disease-free survival (DFS) at all time points compared to liver resection (LR) in adults with single-nodule HCC, based on observational data.
ContextRefines current practice by providing meta-analytic evidence favoring LT over LR for long-term outcomes in single-nodule HCC, though prior debate persists due to observational data limitations.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Rosa-Sánchez C … Redondo-Cerezo E · Journal of Hepato-Biliary-Pancreatic Sciences · IF 3.8 · PubMed ↗Permalink
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