← Issue №14/ week of Oct 4, 2026/Hepatology

Hypothermic oxygenated and normothermic machine perfusion mitigate innate systemic and hepatic inflammation after liver transplantation.

From GI Signals issue №14: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Hepatology rct · n=47 · Sep 29, 2026 · Gut · IF 24.6

Hypothermic oxygenated and normothermic machine perfusion mitigate innate systemic and hepatic inflammation after liver transplantation.

Basic sciencebasic sciencetranslationalliver transplantbiomarker
Clinical takeawayNo clinical action yet: a mechanistic finding in humans showing immune modulation by machine perfusion in liver transplantation.
What it foundHOPE and NMP reduced neutrophil infiltration during early IRI and normalized peripheral lymphocyte numbers faster compared to SCS, with HOPE showing lower systemic neutrophil numbers.
ContextThis study provides mechanistic evidence supporting the immunological benefits of machine perfusion over static cold storage in liver transplantation, refining understanding of its impact on immune responses.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Lurje I … Lurje G · Gut · IF 24.6 · PubMed ↗Permalink
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