Hepatology
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See the full rubric →Urea-to-Creatinine-Ratio and the risk of 28-day mortality in critically ill adults with or without Acute Kidney Injury: A post-hoc analysis of a randomized clinical trial.
Clinical takeawayFurther research is needed to determine if monitoring urea-to-creatinine ratio on Day 7 in critically ill patients without baseline acute kidney injury can improve outcomes, as both low and high values are associated with increased 28-day mortality.
What it foundDay 7 urea-to-creatinine ratio showed a U-shaped association with 28-day mortality in patients without baseline acute kidney injury, with adjusted hazard ratios of 2.06 (95% CI, 1.30-3.26) for low and 2.21 (95% CI, 1.45-3.38) for high ratios.
ContextThis study identifies a U-shaped association between Day 7 urea-to-creatinine ratio and 28-day mortality in critically ill patients without baseline acute kidney injury, refining prior evidence by specifying timing and subgroup.
No standard claimed for this paper
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Zhou L … Chinese Critical Care Nutrition Trials Group (CCCNTG) · JPEN. Journal of Parenteral and Enteral Nutrition · IF 3.2 · PubMed ↗