Motility
Signal score, how each part rates
ActionabilityPrevalenceStakesEvidence strengthNovelty
See the full rubric →Orthostatic Intolerance in Patients With Disorders of Gut-Brain Interaction: A Systematic Review and Meta-Analysis.
Clinical takeawayConsider screening for orthostatic intolerance (OI) and POTS in patients with severe DGBI, particularly pediatric patients and those diagnosed using Rome IV criteria or questionnaire-based methods, as these groups show higher prevalence. Be cautious due to clinical heterogeneity and low-quality evidence.
What it foundOI prevalence in DGBI patients was 50.0% (95% CI: 35.0-64.9), with odds 5.17 times higher than controls (95% CI: 1.73-15.50, P=0.003). Pediatric patients had a higher prevalence (59.7%, 95% CI: 36.4-79.3) than adults (32.5%, 95% CI: 19.3-49.4). OI prevalence was higher with Rome IV criteria (66.1%, 95% CI: 43.3-83.3) vs. Rome III (30.6%, 95% CI: 21.4-41.6) and with questionnaire-based diagnosis (54.5%, 95% CI: 9.7-93.0) vs. physician-based (48.8%, 95% CI: 35.2-62.7). POTS prevalence was 31.5% (95% CI: 17.3-50.2).
ContextConfirms the association between severe DGBI and OI, with higher prevalence in pediatric patients, Rome IV-diagnosed cases, and questionnaire-based diagnoses, but highlights clinical heterogeneity and low-quality evidence.
No standard claimed for this paper
Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.
Ayaki K … Holtmann G · Journal of Clinical Gastroenterology · IF 2.9 · PubMed ↗