Hepatology
Signal score, how each part rates
ActionabilityPrevalenceStakesEvidence strengthNovelty
See the full rubric →Diagnostic Value and Influencing Factors of Ultrasound-Derived Fat Fraction for Quantifying MASLD in Children.
Clinical takeawayConsider using UDFF as a non-invasive, accurate, and reproducible tool for screening, staging, and longitudinal follow-up of paediatric MASLD, particularly in mild-to-moderate cases. Be cautious in severe steatosis due to a systematic numerical bias (-9.23%) compared to MRI-PDFF.
What it foundUDFF had an AUC of 0.98 for detecting steatosis (≥6.4%) with an optimal cutoff of 5.5% (sensitivity 97.6%, specificity 92.9%, accuracy 95.7%).
ContextThis study confirms UDFF as a viable alternative to MRI-PDFF for quantifying hepatic steatosis in children, aligning with current efforts to reduce reliance on costly and invasive imaging.
No standard claimed for this paper
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Zheng X … Chen J · Liver International : Official Journal of the International Association for the Study of the Liver · IF 6.7 · PubMed ↗