← Issue №14/ week of Oct 4, 2026/Hepatology

Liver transplantation for primary liver cancers in the era of transplant oncology.

From GI Signals issue №14: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Hepatology review · Oct 1, 2026 · J Hepatology · IF 40.1

Liver transplantation for primary liver cancers in the era of transplant oncology.

Guideline / reviewliver transplanthepatocellular carcinomabiomarkertranslational
Clinical takeawayConsider LT as a multi-step process for selected patients with primary liver cancer, incorporating neoadjuvant strategies (bridging, downstaging, conversion therapies) and post-transplant immunosuppression minimization to balance graft preservation and tumor immune surveillance.
What it foundLiver transplantation (LT) remains the most effective curative-intent surgical approach for selected patients with primary hepatic malignancies, with eligibility determined by a dynamic 'window of eligibility' based on predicted overall survival and transplant benefit.
ContextConfirms and refines current practice by emphasizing the dynamic assessment of transplant candidacy and the integration of neoadjuvant therapies to expand eligibility for advanced disease.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Mazzaferro V … Tabrizian P · Journal of Hepatology · IF 40.1 · PubMed ↗Permalink
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