IBD
Signal score, how each part rates
ActionabilityPrevalenceStakesEvidence strengthNovelty
See the full rubric →Histological aging signatures for monitoring tissue-specific aging and disease.
Clinical takeawayNo clinical action yet: tissue-specific aging biomarkers have been identified and correlate with disease presence and comorbidities, but prospective studies are needed to determine whether monitoring tissue-age acceleration predicts clinical outcomes or guides treatment.
What it foundDeveloped tissue clocks from deep learning analysis of 25,712 histopathology images (40 tissue types) that predict tissue-specific biological age and correlate with telomere attrition, subclinical pathology, and comorbidities; identified disease-relevant organ aging patterns in eight diseases including Crohn's disease.
ContextRefines the understanding of aging by demonstrating that tissue-specific architectural patterns can be quantified and predict biological age; tissue clocks correlate with disease presence, suggesting aging manifests heterogeneously across organ systems.
No standard claimed for this paper
Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.
Abila E … Rendeiro AF · Nature Medicine · IF 52.5 · PubMed ↗