Hepatology
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See the full rubric →Threshold-Defined Liver Stiffness Trajectories and Liver-Related Event Risk in Chronic Liver Disease: A Cohort Study.
Clinical takeawayConsider more frequent monitoring (e.g., biannual liver stiffness tests) for patients with chronic liver disease and Persistent High liver stiffness (≥10 kPa), especially those with non-viral aetiologies (HR 6.4 vs 2.6 for viral), pending external validation of these findings.
What it foundPatients with Persistent High liver stiffness (≥10 kPa, per Baveno VII criteria) had a 15.0% 3-year risk of liver-related events (LREs), accounting for 61.9% of all LREs, with HR 4.1 (3.1-5.5) vs Stable Low.
ContextRefines risk stratification by showing that Persistent High liver stiffness, even with numerical decreases, concentrates most LRE risk, particularly in non-viral aetiologies. The findings require external validation.
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Kim DY … Kim SU · Liver International : Official Journal of the International Association for the Study of the Liver · IF 6.7 · PubMed ↗