← Issue №2/ week of Jul 12, 2026/Colorectal

Three-Year Follow-Up of the Randomized Trial Comparing Open Versus Laparoscopic Surgery for Primary Tumor Resection in Patients With Non-Curable Stage IV Colon Cancer (JCOG1107).

From GI Signals issue №2: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Colorectal rct · n=195 · Jul 16, 2026 · Dis Colon Rectum · IF 3.5

Three-Year Follow-Up of the Randomized Trial Comparing Open Versus Laparoscopic Surgery for Primary Tumor Resection in Patients With Non-Curable Stage IV Colon Cancer (JCOG1107).

New evidencecolorectal cancercolorectal surgery
Clinical takeawayConsider laparoscopic surgery as an acceptable option for symptomatic non-curable stage IV colon cancer (with 1-3 non-curable factors, stenosis/bleeding, primary tumor cecum to rectosigmoid), given its non-inferiority to open surgery in progression-free survival and comparable complication rates.
What it found3-year progression-free survival was 5.3% for open surgery vs 3.0% for laparoscopic surgery (HR 1.028, 95% CI 0.772-1.370; non-inferiority p=0.02), with no significant difference in 3-year overall survival (31.5% vs 28.5%).
ContextConfirms laparoscopic surgery as non-inferior to open surgery in this population, aligning with prior evidence but now with longer-term (3-year) outcomes.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Shiomi A … Inomata M · Diseases of the Colon and Rectum · IF 3.5 · PubMed ↗Permalink
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