← Issue №2/ week of Jul 12, 2026/ the whole section, in full

Colorectal, in full.

All 2 Colorectal papers in this issue, as full cards, ranked by clinical utility. The issue page carries the strongest few; this is the section, whole.

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IBD1Hepatology5Esophagus/Reflux2Pancreas/Biliary2Endoscopy5Colorectal2
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Colorectal rct · n=195 · Jul 16, 2026 · Dis Colon Rectum · IF 3.5

Three-Year Follow-Up of the Randomized Trial Comparing Open Versus Laparoscopic Surgery for Primary Tumor Resection in Patients With Non-Curable Stage IV Colon Cancer (JCOG1107).

New evidencecolorectal cancercolorectal surgery
Clinical takeawayConsider laparoscopic surgery as an acceptable option for symptomatic non-curable stage IV colon cancer (with 1-3 non-curable factors, stenosis/bleeding, primary tumor cecum to rectosigmoid), given its non-inferiority to open surgery in progression-free survival and comparable complication rates.
What it found3-year progression-free survival was 5.3% for open surgery vs 3.0% for laparoscopic surgery (HR 1.028, 95% CI 0.772-1.370; non-inferiority p=0.02), with no significant difference in 3-year overall survival (31.5% vs 28.5%).
ContextConfirms laparoscopic surgery as non-inferior to open surgery in this population, aligning with prior evidence but now with longer-term (3-year) outcomes.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Shiomi A … Inomata M · Diseases of the Colon and Rectum · IF 3.5 · PubMed ↗Permalink
Colorectal prospective cohort · n=1,956,948 · Jul 15, 2026 · BMJ · IF 42.7

Contemporary hormonal contraception and colorectal cancer in premenopausal women: nationwide cohort study.

New evidencecolorectal cancerepidemiology
Clinical takeawayNo need to modify contraceptive counseling or colorectal cancer screening practices based on hormonal contraceptive use in premenopausal women aged 15-49, as modern products neither increase nor decrease risk.
What it foundCurrent or recent use of contemporary hormonal contraception did not substantially affect colorectal cancer risk, with incidence rate ratios of 0.94 (95% CI 0.83 to 1.06) for all users and 0.86 (0.62 to 1.18) for those with more than 10 years of use.
ContextThis confirms prior evidence that hormonal contraception does not significantly influence colorectal cancer risk, addressing concerns about rising incidence in young women.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Lange IH … Mørch LS · BMJ · IF 42.7 · PubMed ↗Permalink
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