← Issue №15/ week of Oct 11, 2026/Endoscopy

Cholangioscopy-guided lithotripsy versus mechanical lithotripsy for large common bile duct stones during balloon enteroscopy-assisted ERCP after gastrectomy with a native papilla.

From GI Signals issue №15: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy retrospective · n=104 · Oct 8, 2026 · Endoscopy · IF 11.8

Cholangioscopy-guided lithotripsy versus mechanical lithotripsy for large common bile duct stones during balloon enteroscopy-assisted ERCP after gastrectomy with a native papilla.

New evidenceERCPcholedocholithiasisendoscopy qualitybiliary stricture
Clinical takeawayConsider a POCL-first strategy for large common bile duct stones in postgastrectomy patients with surgically altered anatomy undergoing BE-ERCP, as it significantly improves initial-session clearance rates compared to ML-first, with no significant difference in adverse event rates.
What it foundPOCL-first strategy achieved complete stone clearance in 95% of initial sessions vs 62% with ML-first (risk difference 33.3%, 95% CI 17.3-46.0).
ContextChallenges current practice of ML-first for large common bile duct stones in postgastrectomy patients with surgically altered anatomy, suggesting POCL-first may be more effective.
Refinessuggested applicable standard· American Society for Gastrointestinal Endoscopy (ASGE), "ASGE guideline on the role of endoscopy in the evaluation and management of choledocholithiasis" (Buxbaum JL et al., Gastrointest Endosc 2019;89(6):1075-1105), 2019

… For large bile-duct stones, the panel suggests endoscopic sphincterotomy followed by large-balloon dilation (ES-LBD) rather than sphincterotomy alone (conditional, moderate); for large AND difficult stones, it suggests intraductal therapy (cholangioscopy-guided EHL or laser lithotripsy) or conventional therapy with papillary dilation, chosen by local expertise, cost, and patient/physician preference (conditional, very low). …

From our summary of this standard, unedited — the part the paper bears on. … marks omitted text. Our wording, not the guideline's; read the source for its own text.

Our full summary of this standard

Risk-stratify suspected choledocholithiasis (high >50%, intermediate 10-50%, low <10% probability). HIGH-risk criteria, any of which should directly prompt ERCP: (1) CBD stone on ultrasound or cross-sectional imaging; (2) ascending cholangitis; (3) total bilirubin >4 mg/dL AND dilated CBD (>6 mm in adults with gallbladder in situ, >8 mm after cholecystectomy). Gallstone pancreatitis was deliberately REMOVED as a high-risk criterion in the 2019 revision. INTERMEDIATE risk (abnormal liver biochemical tests, age >55 y, or bile-duct dilation on imaging): the panel suggests confirmation with either EUS or MRCP (conditional recommendation, low-quality evidence; choice by patient preference, local expertise, availability), laparoscopic intraoperative cholangiography (IOC) or intraoperative US are equally sanctioned alternatives. LOW risk: cholecystectomy with or without IOC/intraoperative US if indicated for symptomatic cholelithiasis; no ERCP and no mandatory advanced biliary imaging. In gallstone pancreatitis WITHOUT cholangitis or biliary obstruction/choledocholithiasis, the panel recommends AGAINST urgent (<48 h) ERCP (strong recommendation, low-quality evidence). Same-admission cholecystectomy is recommended for patients with MILD gallstone pancreatitis (consensus, PONCHO-based); ERCP with prophylactic sphincterotomy should not be used as an alternative to cholecystectomy unless surgery is absolutely contraindicated (e.g., recurrent pancreatitis in end-stage liver disease). For large bile-duct stones, the panel suggests endoscopic sphincterotomy followed by large-balloon dilation (ES-LBD) rather than sphincterotomy alone (conditional, moderate); for large AND difficult stones, it suggests intraductal therapy (cholangioscopy-guided EHL or laser lithotripsy) or conventional therapy with papillary dilation, chosen by local expertise, cost, and patient/physician preference (conditional, very low). Timing versus cholecystectomy: pre- or postoperative ERCP or laparoscopic bile-duct clearance for patients at high risk or with positive IOC, depending on local surgical and endoscopic expertise (consensus).

American Society for Gastrointestinal Endoscopy (ASGE), "ASGE guideline on the role of endoscopy in the evaluation and management of choledocholithiasis" (Buxbaum JL et al., Gastrointest Endosc 2019;89(6):1075-1105), 2019 · reviewed 2026-07-19 ↗
Inoue T … Ito K · Endoscopy · IF 11.8 · PubMed ↗Permalink
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