IBD
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See the full rubric →Association between Crohn's disease and pulmonary nodule patterns: an inverse probability-weighted analysis of real-world data.
Clinical takeawayNo change in practice: manage incidental nodules by standard radiology criteria. Nodule burden in CD rose with age, not with disease phenotype or extraintestinal manifestations; adalimumab correlated with fewer non-solid and 6-8 mm nodules, an observational association of unclear meaning.
What it foundCD patients had higher pulmonary nodule counts (solid nodules IRR 1.80, 95% CI 1.62-1.98) and adalimumab correlated with fewer non-solid and 6-8 mm nodules (IRR 0.615-0.676).
ContextConfirms CD's systemic impact on pulmonary nodules in adults but challenges the utility of disease phenotype for risk stratification, shifting focus to age and medication exposures. Findings are based on a retrospective multicenter cohort study of 2,009 CD patients and 4,002 controls.
No standard claimed for this paper
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Cai C … Mimic Inflammatory Bowel Disease Study Group · Clinical and Translational Gastroenterology · IF 3.4 · PubMed ↗