← Issue №15/ week of Oct 11, 2026/Endoscopy

Short- and Long-Term Outcomes of Underwater Versus Conventional Colorectal Endoscopic Submucosal Dissection: A Large Retrospective Real-World Cohort Study.

From GI Signals issue №15: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy retrospective · n=1,635 · Oct 7, 2026 · Endoscopy · IF 11.8

Short- and Long-Term Outcomes of Underwater Versus Conventional Colorectal Endoscopic Submucosal Dissection: A Large Retrospective Real-World Cohort Study.

New evidenceESDcolorectal cancerendoscopy qualitycomputer-aided detection
Clinical takeawayConsider underwater ESD for technical advantages in dissection speed compared to conventional ESD, but do not expect shorter procedure times or improved resection outcomes. Adverse events were similar between groups.
What it foundUnderwater ESD increased dissection speed by 23% (speed ratio 1.23, 95% CI 1.14-1.32) but did not reduce procedure time or improve resection outcomes.
ContextConfirms prior reports of underwater ESD's technical benefits but challenges assumptions of broader procedural improvements in colorectal ESD lesions at a tertiary referral center.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Murata S … Kato M · Endoscopy · IF 11.8 · PubMed ↗Permalink
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