← Issue №15/ week of Oct 11, 2026/Endoscopy

Real-Time Computer-Aided Detection During Colonoscopy-Effects on Advanced, Diminutive, and Non-Neoplastic Lesion Detection: A Systematic Review and Meta-Analysis of Randomized Trials.

From GI Signals issue №15: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy meta analysis · n=10,247 · Oct 7, 2026 · Dig Dis Sci · IF 2.5

Real-Time Computer-Aided Detection During Colonoscopy-Effects on Advanced, Diminutive, and Non-Neoplastic Lesion Detection: A Systematic Review and Meta-Analysis of Randomized Trials.

New evidencecomputer-aided detectioncolonoscopymeta-analysisartificial intelligence
Clinical takeawayDo not adopt CADe solely for advanced adenoma detection, as it did not improve detection of clinically consequential neoplasia compared to non-CADe colonoscopy despite increasing overall ADR.
What it foundCADe increased overall ADR by 16% (RR 1.16, 95% CI 1.12-1.20) and non-neoplastic lesion detection by 16% (RR 1.16, 95% CI 1.03-1.31), but did not increase advanced adenoma detection (RR 1.03, 95% CI 0.97-1.10) or adenomas ≥10 mm (RR 1.18, 95% CI 0.92-1.53).
ContextChallenges the assumption that higher ADR with CADe translates to better detection of advanced neoplasia, refining its clinical utility in average-risk colorectal cancer screening.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Anthony AE … Nemeth ZH · Digestive Diseases and Sciences · IF 2.5 · PubMed ↗Permalink
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