IBD
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See the full rubric →Early Colectomy and Long-Term Risk of Cardiometabolic Disease in Ulcerative Colitis: A Nationwide Cohort Study.
Clinical takeawayDecide on colectomy by disease control, dysplasia and patient preference, not cardiometabolic risk. In this matched Swedish cohort the lower cardiovascular and diabetes rates after early colectomy did not reach significance (aHR 0.68, 95% CI 0.44-1.06; aHR 0.76, 95% CI 0.39-1.48) and are open to confounding.
What it foundEarly colectomy in UC patients was associated with a 32% lower risk of CVD (aHR 0.68, 95% CI 0.44-1.06) compared to patients without early colectomy and a numerically lower risk of DM2 (aHR 0.76, 95% CI 0.39-1.48) over a median follow-up of 9 years, though the CVD risk reduction did not reach statistical significance.
ContextThis study suggests a potential benefit of early colectomy beyond IBD-related outcomes, challenging the traditional view of colectomy as a last-resort intervention in UC.
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Faye AS … Ludvigsson JF · American Journal of Gastroenterology · IF 9.8 · PubMed ↗