← Issue №15/ week of Oct 11, 2026/Colorectal

Rates of Aerodigestive Cancer After Positive mt-sDNA and Colonoscopy Without Advanced Colorectal Neoplasia in Patients with a Prior Cancer History.

From GI Signals issue №15: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Colorectal retrospective · n=65 · Oct 6, 2026 · Dig Dis Sci · IF 2.5

Rates of Aerodigestive Cancer After Positive mt-sDNA and Colonoscopy Without Advanced Colorectal Neoplasia in Patients with a Prior Cancer History.

New evidencecolorectal cancercolorectal cancer screeningbiomarkerepidemiology
Clinical takeawayNo clinical action yet: this retrospective study highlights a potential association but does not support changes in surveillance or management.
What it found22% of patients with a positive mt-sDNA result and negative colonoscopy developed new or recurrent cancer, with 93% involving the aerodigestive tract.
ContextThis study raises questions about the implications of positive mt-sDNA results in patients with prior non-CRC malignancy, an area with limited prior evidence.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Patel S … Mendelsohn RB · Digestive Diseases and Sciences · IF 2.5 · PubMed ↗Permalink
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