← Issue №15/ week of Oct 11, 2026/Motility

Focal Hypoganglionosis-Associated Adult-Onset Megacolon: A Localized Enteric Neuropathy Distinct From Chronic Intestinal Pseudo-Obstruction.

From GI Signals issue №15: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Motility review · Oct 7, 2026 · J Neurogastro Motil · IF 3.4

Focal Hypoganglionosis-Associated Adult-Onset Megacolon: A Localized Enteric Neuropathy Distinct From Chronic Intestinal Pseudo-Obstruction.

New evidencechronic constipationbasic sciencetranslational
Clinical takeawayConsider FHAM as a distinct diagnosis in adults with severe chronic constipation, focal colonic narrowing, and proximal megacolon, and evaluate for surgical intervention when appropriate, recognizing the risks and benefits of surgery.
What it foundFHAM patients had markedly lower postoperative reoperation rates (2.5% vs. 66.7%) and long-term TPN requirement (0% vs. 46.2%) compared to CIPO patients following surgical resection.
ContextChallenges the traditional classification of adult-onset megacolon within idiopathic megacolon or CIPO, introducing FHAM as a surgically remediable phenotype with better outcomes compared to CIPO.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Jung KW … Myung SJ · Journal of Neurogastroenterology and Motility · IF 3.4 · PubMed ↗Permalink
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