← Issue №15/ week of Oct 11, 2026/Colorectal

Accelerated Biological Aging and Risk of Early-Onset Colorectal Cancer: Findings from a Large Prospective East Asian Cohort.

From GI Signals issue №15: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Colorectal prospective cohort · n=198,491 · Oct 5, 2026 · Clin Gastro Hep · IF 16.2

Accelerated Biological Aging and Risk of Early-Onset Colorectal Cancer: Findings from a Large Prospective East Asian Cohort.

Basic scienceepidemiologybiomarkercolorectal cancer
Clinical takeawayNo screening change: PhenoAge is a research measure derived from nine routine labs and has no validated threshold for CRC risk. The association (HR 1.93, 95% CI 1.28-2.91; 127 cases among 198,491 adults under 50) supports biological aging as a risk marker worth validating.
What it foundAccelerated biological aging (biological age > chronological age) increased early-onset colorectal adenocarcinoma (EOCRC-AC) risk by 93% (HR 1.93, 95% CI 1.28-2.91), particularly for colon adenocarcinoma (HR 2.32, 95% CI 1.38-3.89).
ContextThis study introduces biological aging as a novel risk factor for EOCRC-AC in a cohort of Korean adults under 50, complementing current chronological age-based screening criteria.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Chang Y … Ryu S · Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association · IF 16.2 · PubMed ↗Permalink
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