← Issue №14/ week of Oct 4, 2026/Motility

Diagnostic Value of the Anal Endoluminal Functional Luminal Imaging Probe for the Diagnosis of Anismus: An Exploratory Study.

From GI Signals issue №14: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Motility prospective cohort · n=57 · Oct 1, 2026 · Neurogastro Motil · IF 3.5

Diagnostic Value of the Anal Endoluminal Functional Luminal Imaging Probe for the Diagnosis of Anismus: An Exploratory Study.

Diagnosticartificial intelligencebiomarkerfunctional dyspepsia
Clinical takeawayConsider using anal EndoFLIP as an adjunctive diagnostic tool for anismus in patients with functional constipation and suspected dyssynergic defecation, particularly to rule out the condition. Note that the thresholds are exploratory and require external validation before clinical adoption.
What it foundA maximal absolute ΔCSA below 12.8 mm2 at 40 mL distension on anal EndoFLIP had 93% specificity and AUC 0.81 for diagnosing anismus in patients with functional constipation and suspected dyssynergic defecation.
ContextThis exploratory study introduces anal EndoFLIP as a potential diagnostic tool for anismus, complementing the current composite reference standard (anorectal manometry, surface electromyography, and defecography).
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Desprez C … Leroi AM · Neurogastroenterology and Motility · IF 3.5 · PubMed ↗Permalink
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