← Issue №14/ week of Oct 4, 2026/Endoscopy

Efficacy and Safety of 1-L Polyethylene Glycol With Low Ascorbic Acid for Bowel Preparation: A Randomized Clinical Trial.

From GI Signals issue №14: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy rct · n=242 · Sep 30, 2026 · J Gastro Hep · IF 3.5

Efficacy and Safety of 1-L Polyethylene Glycol With Low Ascorbic Acid for Bowel Preparation: A Randomized Clinical Trial.

New evidencecolonoscopyendoscopy qualitycolorectal cancer screening
Clinical takeawayConsider using 1-L PEG + low Asc for bowel preparation in low-risk adults undergoing colonoscopy, as it is noninferior to standard regimens with comparable tolerability and safety.
What it found1-L PEG + low Asc achieved 92.7% successful bowel cleansing (Harefield Cleansing Scale), noninferior to 1-L PEG + Asc (100%) and 2-L PEG + Asc (98.7%) within a 13% margin.
ContextRefines current practice by showing that reducing ascorbic acid dose in 1-L PEG regimens maintains efficacy while potentially lowering adverse event risks.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Baek JE … Lee KM · Journal of Gastroenterology and Hepatology · IF 3.5 · PubMed ↗Permalink
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