← Issue №13/ week of Sep 27, 2026/Hepatology

Global burden of liver disease: 2026 update.

From GI Signals issue №13: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Hepatology review · Sep 25, 2026 · Gastroenterology · IF 25.1

Global burden of liver disease: 2026 update.

Epidemiologyepidemiologyhealth servicescost-effectivenessviral hepatitis
Clinical takeawayNo clinical action yet: this is an epidemiology review highlighting global disparities in liver disease burden and access to care.
What it foundChronic liver disease affects over 1.5 billion people globally, with cirrhosis and primary liver cancer causing 2.4 million deaths annually, disproportionately in low- and middle-income countries.
ContextConfirms the substantial and growing global burden of liver disease, driven by alcohol-associated liver disease, MASLD, and viral hepatitis, with widening regional disparities in outcomes.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Devarbhavi H … Kamath PS · Gastroenterology · IF 25.1 · PubMed ↗Permalink
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