← Issue №13/ week of Sep 27, 2026/Endoscopy

The Relationship Between Selective Serotonin Reuptake Inhibitor Use and Delayed Bleeding After Colorectal Endoscopic Resection: A Nationwide Retrospective Cohort Study.

From GI Signals issue №13: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy retrospective · n=169,995 · Sep 23, 2026 · Dig Dis Sci · IF 2.5

The Relationship Between Selective Serotonin Reuptake Inhibitor Use and Delayed Bleeding After Colorectal Endoscopic Resection: A Nationwide Retrospective Cohort Study.

New evidencecolorectal cancer screeningpolypectomyhemostasis
Clinical takeawayNo change in SSRI management before CER is currently justified, but further evidence is needed, particularly for ESD and resection of large lesions, to fully assess bleeding risk.
What it foundSSRI use was not significantly associated with delayed bleeding after colorectal endoscopic resection (0.77% vs 0.69%, OR 1.12, 95% CI 0.71-1.77), but the wide confidence interval could not exclude a clinically meaningful moderate increase in risk.
ContextConfirms prior uncertainty: SSRIs are known to increase GI bleeding risk, but this large cohort found no clear signal for delayed bleeding post-CER, though a moderate effect cannot be ruled out.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Asano H … Fujishiro M · Digestive Diseases and Sciences · IF 2.5 · PubMed ↗Permalink
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