Hepatology
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See the full rubric →Early predictors of pruritus response in children with PFIC treated with odevixibat.
Clinical takeawayMonitor sBA levels at 1 and 3 months in children with PFIC on odevixibat; reductions ≥48% at 1 month or ≥52% at 3 months from baseline suggest likelihood of pruritus response by 6 months.
What it foundReductions in serum bile acid (sBA) levels ≥48% at 1 month (AUC 0.771; sensitivity 0.75, specificity 0.83) and ≥52% at 3 months (AUC 0.885; sensitivity 0.81, specificity 1.00) from baseline predicted pruritus response (≥1-point improvement) at 6 months in children with PFIC treated with odevixibat.
ContextIdentifies early biomarkers for response to odevixibat in children with PFIC, a rare but debilitating condition with limited treatment options.
No standard claimed for this paper
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Di Giorgio A … D'Antiga L · Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · IF 4.2 · PubMed ↗