← Issue №13/ week of Sep 27, 2026/Hepatology

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study.

From GI Signals issue №13: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Hepatology prospective cohort · n=679 · Sep 21, 2026 · Gut · IF 24.6

Hospitalisation in cirrhosis is linked to distinct gut microbiome structural and functional profiles: a multinational metagenomic study.

New evidencemicrobiomebiomarkerepidemiologyartificial intelligence
Clinical takeawayNo clinical action yet: a microbiome signature associated with hospitalization risk in cirrhosis, not yet validated for clinical use.
What it foundA combined clinical-microbiome model predicted 90-day hospitalization in cirrhosis with AUC 0.84, outperforming clinical-only (AUC 0.79) and microbiome-only (AUC 0.74) models.
ContextExtends prior evidence linking gut microbiome to cirrhosis outcomes by identifying specific taxa and functional pathways associated with hospitalization risk across diverse populations.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Nikitina D … Bajaj JS · Gut · IF 24.6 · PubMed ↗Permalink
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