← Issue №12/ week of Sep 20, 2026/Endoscopy

Heparin Wet Suction Versus Conventional Suction in Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Solid Pancreatic Masses: A Multicenter Randomized Crossover Study.

From GI Signals issue №12: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy rct · n=170 · Sep 20, 2026 · J Gastro Hep · IF 3.5

Heparin Wet Suction Versus Conventional Suction in Endoscopic Ultrasound-Guided Fine-Needle Biopsy for Solid Pancreatic Masses: A Multicenter Randomized Crossover Study.

New evidenceEUSpancreatic cancerendoscopy qualitybiomarker
Clinical takeawayNo need to switch from conventional suction to heparin wet suction for EUS-FNB of solid pancreatic masses: both techniques perform equally well.
What it foundDiagnostic yield was 82.9% with heparin wet suction (HWST) vs 83.5% with conventional suction (CST), a non-significant difference (95% CI -6.7 to 5.5). Combined yield after sequential sampling was 91.2%.
ContextHWST was proposed to improve tissue quality by reducing blood clots, but this trial found no advantage over standard suction in diagnostic yield, technical success, or IHC adequacy.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Chon HK … Lee SH · Journal of Gastroenterology and Hepatology · IF 3.5 · PubMed ↗Permalink
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