← Issue №12/ week of Sep 20, 2026/Endoscopy

Efficacy and safety of novel VAC-Stent in management of upper gastrointestinal post-surgical leaks: results from a large multicenter study in tertiary referral centers.

From GI Signals issue №12: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy retrospective · n=81 · Sep 18, 2026 · GIE · IF 8.0

Efficacy and safety of novel VAC-Stent in management of upper gastrointestinal post-surgical leaks: results from a large multicenter study in tertiary referral centers.

New therapyERCP
Clinical takeawayConsider VAC-Stent for post-surgical upper GI leaks in tertiary centers where combined SEMS/EVT capability exists, weighing against standard SEMS or EVT alone.
What it foundVAC-Stent achieved complete healing in 85.3% of patients (64/75) with upper GI post-surgical leaks (vs historical SEMS/EVT outcomes), with successful deployment in 100% of cases (150/150) and 1 late bleeding event managed conservatively.
ContextRetrospective multicenter study of 81 patients with post-surgical UGI leaks (mean defect size 19.6 ± 18.2 mm) treated with novel SEMS-EVT hybrid device.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Zito FP … Lombardi G · Gastrointestinal Endoscopy · IF 8.0 · PubMed ↗Permalink
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