Colorectal
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ActionabilityPrevalenceStakesEvidence strengthNovelty
See the full rubric →The influence of tumor side, sex, and screening on colon cancer stage and survival: a 25-year population-based study.
Clinical takeawayConsider prioritizing FIT-based screening for older patients, particularly women, and men with advanced-stage disease, given the increased incidence and worse prognosis of right-sided colon cancer in these groups.
What it foundRight-sided colon cancer incidence increased with aging (p ≤ 0.001) and was associated with female sex (OR 1.40, 95% CI 1.27-1.54), advanced stage in men (node-positive: OR 1.54, 95% CI 1.17-2.02; metastatic: OR 1.47, 95% CI 1.06-2.03), and worse prognosis in men (HR 1.16, 95% CI 1.01-1.34) compared to left-sided colon cancer.
ContextConfirms and refines prior evidence on the divergent behavior of right- and left-sided colon cancer, emphasizing the role of tumor side, sex, and screening impact in stage and survival outcomes in older patients, women, and men with advanced-stage disease.
Refinessuggested applicable standard· U.S. Multi-Society Task Force on Colorectal Cancer (Rex DK, Boland CR, Dominitz JA, et al.), "Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2017
Decision at stakethe choice of colorectal cancer screening modality
U.S. Multi-Society Task Force on Colorectal Cancer (Rex DK, Boland CR, Dominitz JA, et al.), "Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2017 · reviewed 2026-07-23 ↗Begin average-risk colorectal cancer screening at age 45 using a patient-centered shared-decision modality choice, colonoscopy every 10 years (preferred) or annual FIT as Tier 1 options, with multi-target stool DNA every 3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 to 10 years as Tier 2 alternatives. A positive stool-based test requires diagnostic colonoscopy, and stool tests should not be ordered for patients who would decline follow-up colonoscopy. Generally stop at age 75 with individualized decisions for ages 76-85 and no screening beyond 85.
Kayali S … Laghi L · Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver · IF 4.2 · PubMed ↗