← Issue №9/ week of Aug 30, 2026/IBD

Serious infections in patients with inflammatory bowel disease and corticosteroids: A propensity score-matched study.

From GI Signals issue №9: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

IBD prospective cohort · n=145,125 · Aug 28, 2026 · Clin Gastro Hep · IF 16.2

Serious infections in patients with inflammatory bowel disease and corticosteroids: A propensity score-matched study.

New evidencebiologicsJAK inhibitorsanti-TNFtherapeutic drug monitoring
Clinical takeawayMinimize corticosteroid duration in IBD, especially in children, and weigh infection risk when considering steroid use in high-risk patients (e.g., prior infections, comorbidities).
What it foundIBD patients on corticosteroids had 3.6-10.2 more serious infections per 100 person-years vs non-users (aHR 4.52-15.86), with highest risk in children and dose-dependent effects.
ContextConfirms and quantifies the known infection risk from corticosteroids in IBD, now with precise estimates across therapies and age groups.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Forss A … Olén O · Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association · IF 16.2 · PubMed ↗Permalink
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