Colorectal
Signal score, how each part rates
ActionabilityPrevalenceStakesEvidence strengthNovelty
See the full rubric →Validation of a Digital Platform for Colorectal Cancer Risk Stratification and Personalized Screening Recommendations.
Clinical takeawayCTC may help identify at-risk individuals and personalize CRC screening recommendations, particularly for higher-risk patients with screening delays (mean 22 years), but further evaluation of patient experience and downstream screening completion is needed before widespread adoption.
What it foundChequeáTuColon (CTC) digital tool showed 100% agreement (κ=1.000) with expert adjudication for CRC risk stratification, alarm symptom detection, genetic evaluation indication, and screening initiation age in a validation study of 395 individuals (median age 59 years).
ContextConfirms that digital risk stratification can match expert judgment, addressing gaps in CRC screening participation and delays, particularly in higher-risk groups.
Refinessuggested applicable standard· U.S. Multi-Society Task Force on Colorectal Cancer (Rex DK, Boland CR, Dominitz JA, et al.), "Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2017
Decision at stakethe use of digital tools for risk stratification and personalized screening recommendations in colorectal cancer screening
U.S. Multi-Society Task Force on Colorectal Cancer (Rex DK, Boland CR, Dominitz JA, et al.), "Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2017 · reviewed 2026-07-23 ↗Begin average-risk colorectal cancer screening at age 45 using a patient-centered shared-decision modality choice, colonoscopy every 10 years (preferred) or annual FIT as Tier 1 options, with multi-target stool DNA every 3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 to 10 years as Tier 2 alternatives. A positive stool-based test requires diagnostic colonoscopy, and stool tests should not be ordered for patients who would decline follow-up colonoscopy. Generally stop at age 75 with individualized decisions for ages 76-85 and no screening beyond 85.
Casas MA … Pereyra L · Digestive Diseases and Sciences · IF 2.5 · PubMed ↗