Efficacy of Primary Endoscopic Bariatric and Metabolic Therapies Combined with Anti-Obesity Medications: A Systematic Review and Meta-Analysis.
Emergingsuggested applicable standard· American Academy of Family Physicians (AAFP) - Gaddey HL, Holder KK. "Unintentional Weight Loss in Older Adults." Am Fam Physician 2021;104(1):34-40. PMID 34264616. NOTE: a peer-reviewed clinical review, NOT a society clinical practice guideline; no GI-society guideline governs the workup of unintentional weight loss (searched Crossref and PubMed 2026-07-31).
Decision at stakethe clinical decision to combine endoscopic bariatric and metabolic therapies with anti-obesity medications for weight loss
Confirm unintentional weight loss (≥5% body weight over 6-12 months, office-weighed) and triage into a three-bucket framework, decreased intake, malabsorption, or hypermetabolic, to direct the evaluation. …
From our summary of this standard, unedited — the part the paper bears on. … marks omitted text. Our wording, not the guideline's; read the source for its own text.
Our full summary of this standard
Confirm unintentional weight loss (≥5% body weight over 6-12 months, office-weighed) and triage into a three-bucket framework, decreased intake, malabsorption, or hypermetabolic, to direct the evaluation. Obtain first-tier labs (CBC, CMP with LFTs, TSH, glucose/A1c, lipase, CRP/ESR, nutritional and iron studies, HIV, and a universal celiac panel) plus mechanism-directed imaging and endoscopy, prioritizing urgent EGD, colonoscopy, or pancreas-protocol CT when malignancy red flags are present. Assess for malnutrition early and initiate nutritional support concurrently with the diagnostic workup, as clinically indicated. Reserve multidisciplinary/PET-CT review for refractory undiagnosed cases.