Colorectal
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See the full rubric →A blood-based test for detection of advanced adenomas and colorectal cancer (DENEB): a multicentre diagnostic accuracy study.
Clinical takeawayCannot assess clinical utility without results: sensitivity, specificity, and diagnostic accuracy for advanced adenoma detection are not reported in this incomplete abstract.
What it foundDENEB is a blood-based miRNA test developed through EDRN phase I-III validation in multicentre cohorts using RT-qPCR and machine learning to identify circulating miRNAs overexpressed in colorectal cancer and advanced adenomas, but the abstract ends in the methods section and does not report diagnostic accuracy.
ContextBlood-based CRC screening tests (Epi proColon, Septin9, Shield, Galleri-based tests) are emerging but variable advanced adenoma detection limits their prevention impact. This miRNA-based approach represents a potential alternative biomarker class pending performance data.
Emergingsuggested applicable standard· U.S. Multi-Society Task Force on Colorectal Cancer (Rex DK, Boland CR, Dominitz JA, et al.), "Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2017
Decision at stakewhether blood-based biomarker tests should be adopted as screening tools
U.S. Multi-Society Task Force on Colorectal Cancer (Rex DK, Boland CR, Dominitz JA, et al.), "Colorectal Cancer Screening: Recommendations for Physicians and Patients From the U.S. Multi-Society Task Force on Colorectal Cancer," Gastroenterology, 2017 · reviewed 2026-07-23 ↗Begin average-risk colorectal cancer screening at age 45 using a patient-centered shared-decision modality choice, colonoscopy every 10 years (preferred) or annual FIT as Tier 1 options, with multi-target stool DNA every 3 years, CT colonography every 5 years, or flexible sigmoidoscopy every 5 to 10 years as Tier 2 alternatives. A positive stool-based test requires diagnostic colonoscopy, and stool tests should not be ordered for patients who would decline follow-up colonoscopy. Generally stop at age 75 with individualized decisions for ages 76-85 and no screening beyond 85.
Mannucci A … Goel A · Lancet Gastroenterology & Hepatology · IF 39.1 · PubMed ↗