Hepatology
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ActionabilityPrevalenceStakesEvidence strengthNovelty
See the full rubric →Liver-on-a-Chip: Applications for clinical modeling of liver disease using microscale systems.
Clinical takeawayNo clinical action yet: this is a review of preclinical technology platforms. LOC systems are research tools that may eventually improve drug development by predicting hepatotoxicity in human-relevant conditions, but they have no direct bedside diagnostic or therapeutic application.
What it foundLiver-on-chip (LOC) systems are microscale in vitro devices incorporating human cells within engineered microdevices with dynamic flow through microchannels, designed to recreate liver spatial oxygen and nutrient gradients and physiologic complexity superior to 2D cell culture for modeling liver disease and screening drug toxicity.
ContextLiver-on-chip represents an evolution bridging traditional 2D cell culture and animal models, offering a human-cell platform for understanding hepatotoxicity and disease mechanisms; the technology remains in development for clinical and commercial implementation.
No standard claimed for this paper
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Brooks NM … Schwartz RE · Hepatology · IF 18.0 · PubMed ↗