← Issue №5/ week of Aug 2, 2026/Endoscopy

Cold snare polypectomy for 5-9mm small-bowel polyps in patients with Peutz-Jeghers syndrome by double-balloon enteroscopy: a prospective clinical trial.

From GI Signals issue №5: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy prospective cohort · n=40 · Aug 3, 2026 · Am J Gastro · IF 9.8

Cold snare polypectomy for 5-9mm small-bowel polyps in patients with Peutz-Jeghers syndrome by double-balloon enteroscopy: a prospective clinical trial.

New evidencepolypectomyendoscopy qualitypediatriccapsule endoscopy
Clinical takeawayConsider CSP for 5-9mm stubby/wide pedicle or sessile small-bowel polyps in PJS patients aged 8-60 years during double-balloon enteroscopy, as it is feasible and safe with low bleeding risk, though larger polyps (8mm) carry higher bleeding risk.
What it foundCold snare polypectomy (CSP) for 5-9mm small-bowel polyps in Peutz-Jeghers syndrome (PJS) had a 5.9% immediate bleeding rate, with bleeding polyps significantly larger (8mm vs 6mm, P < 0.001). No perforation or delayed bleeding occurred.
ContextProspective trial confirms CSP as a viable option for small-bowel polyps in PJS, with complication rates lower than historical reports of hot snare or other techniques (no direct comparison in this study).
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Zeng S … Zuo XL · American Journal of Gastroenterology · IF 9.8 · PubMed ↗Permalink
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