← Issue №5/ week of Aug 2, 2026/Motility

Glucagon-like peptide-1 analogues in the management of high output stoma in adult patients: A narrative review.

From GI Signals issue №5: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Motility review · Jul 30, 2026 · JPEN · IF 3.2

Glucagon-like peptide-1 analogues in the management of high output stoma in adult patients: A narrative review.

New evidencebasic sciencetranslational
Clinical takeawayNo clinical action yet: evidence is based on case reports and small observational studies. Await randomized controlled trials for definitive evidence.
What it foundGLP-1 analogues reduced stoma output and parenteral support requirements compared to baseline in small case reports and observational studies, with nausea as the most common adverse effect.
ContextProposes GLP-1 analogues as a potential novel option for refractory high output stoma, where conventional treatments often fail.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Tuttle Z, Niewiadomski O · JPEN. Journal of Parenteral and Enteral Nutrition · IF 3.2 · PubMed ↗Permalink
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