← Issue №4/ week of Jul 26, 2026/Endoscopy

The Effect of Nexpowder in Reducing Post-ESD Coagulation Syndrome in Proximal Colon Lesions: A Retrospective Multicenter Study.

From GI Signals issue №4: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy retrospective · n=75 · Jul 28, 2026 · J Gastro Hep · IF 3.5

The Effect of Nexpowder in Reducing Post-ESD Coagulation Syndrome in Proximal Colon Lesions: A Retrospective Multicenter Study.

New evidenceESDhemostasiscolorectal cancer
Clinical takeawayProphylactic Nexpowder may reduce PECS risk in high-risk proximal colorectal ESD, but efficacy requires confirmation in prospective trials.
What it foundNexpowder was associated with lower PECS incidence (2.9% [CI 0.3-12.6]) vs no prophylaxis (20.0% [CI 9.9-34.2], p=0.032) in high-risk proximal colon ESD.
ContextFirst clinical evidence suggesting a topical barrier agent for PECS prevention; retrospective data with no standard prophylaxis comparator.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Lee WM … Ko BM · Journal of Gastroenterology and Hepatology · IF 3.5 · PubMed ↗Permalink
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