← Issue №4/ week of Jul 26, 2026/Endoscopy

Combined prophylactic vessel coagulation and high-density complete defect closure after colorectal endoscopic submucosal dissection.

From GI Signals issue №4: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy retrospective · n=174 · Jul 24, 2026 · GIE · IF 8.0

Combined prophylactic vessel coagulation and high-density complete defect closure after colorectal endoscopic submucosal dissection.

New evidenceESDhemostasis
Clinical takeawayConsider combining prophylactic vessel coagulation with high-density complete defect closure (using standard clips or advanced closure devices) after colorectal ESD to reduce delayed bleeding and adverse events, noting that cases with intraprocedural perforation, incomplete closure, or use of hemostatic gels or powders were excluded.
What it foundCombining prophylactic vessel coagulation with high-density complete defect closure after colorectal ESD reduced delayed bleeding to 0% vs 6.9% and composite delayed adverse events to 3.5% vs 12.7%, compared to coagulation alone.
ContextThe literature reports that combining prophylactic vessel coagulation with high-density complete defect closure may improve safety outcomes in colorectal endoscopic submucosal dissection, though evidence is limited to a single study.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

de Sire R … Maselli R · Gastrointestinal Endoscopy · IF 8.0 · PubMed ↗Permalink
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