Colorectal
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See the full rubric →Consensus guidance of immune checkpoint inhibitors in locally advanced rectal cancer.
Clinical takeawayConsider integrating perioperative immunotherapy and organ-preserving strategies into treatment plans for LARC patients, guided by the consensus recommendations. Ensure multidisciplinary team involvement, adherence to mismatch repair/microsatellite instability detection standards, and monitor for safety signals related to perioperative immunotherapy.
What it foundThe consensus provides graded recommendations for preoperative immunotherapy duration, postoperative adjuvant therapy, local resection, and organ preservation strategies in locally advanced rectal cancer (LARC), based on key clinical trials and emphasizing multidisciplinary team involvement.
ContextThis consensus refines and updates perioperative and organ-preserving treatment strategies for LARC, building on recent clinical trial evidence and addressing gaps in prior guidelines, with a focus on safety and efficacy.
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Yang Z … Chinese Society of Colorectal Surgery CNSCRS · Gut · IF 24.6 · PubMed ↗