← Issue №14/ week of Oct 4, 2026/Endoscopy

Cold Versus Hot Endoscopic Mucosal Resection for ≥15 mm Large Nonpedunculated Colorectal Polyps: A Cost-Effectiveness Analysis.

From GI Signals issue №14: what this paper found, what it changes, and where it sits against the current standard of care, reviewed by Simon Mathews, MD.

Endoscopy meta analysis · n=1,442 · Oct 1, 2026 · J Clin Gastro · IF 2.9

Cold Versus Hot Endoscopic Mucosal Resection for ≥15 mm Large Nonpedunculated Colorectal Polyps: A Cost-Effectiveness Analysis.

New evidencecost-effectivenesspolypectomyEMRcolorectal cancer screening
Clinical takeawayConsider C-EMR over H-EMR for LNPCPs ≥15 mm due to its cost-effectiveness and lower risk of adverse events, despite slightly higher recurrence rates compared to H-EMR.
What it foundCold EMR (C-EMR) was cost-effective vs hot EMR (H-EMR) for LNPCPs ≥15 mm, with an ICER of -$669,448 per QALY.
ContextRefines current practice by providing cost-effectiveness evidence favoring C-EMR over H-EMR, which is standard but carries higher risks of delayed bleeding and perforation.
No standard claimed for this paper

Every paper is compared to the standard governing its question. This one is not: either no standard in the corpus matches it, or the comparison did not hold up on review and was withdrawn rather than published unverified. Both are logged.

Sonaiya S … Mohan BP · Journal of Clinical Gastroenterology · IF 2.9 · PubMed ↗Permalink
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