{
  "version": "https://jsonfeed.org/version/1.1",
  "title": "GI Signals - Colorectal",
  "home_page_url": "https://siftingsignal.com/gisignals/",
  "feed_url": "https://siftingsignal.com/gisignals/feed/colorectal.json",
  "description": "Colorectal papers worth knowing in GI this week. A SiftingSignal publication.",
  "items": [
    {
      "id": "https://siftingsignal.com/gisignals/2026-W29/#card-pmid-42457240",
      "url": "https://siftingsignal.com/gisignals/2026-W29/#card-pmid-42457240",
      "title": "Contemporary hormonal contraception and colorectal cancer in premenopausal women: nationwide cohort study.",
      "date_published": "2026-07-18T20:04:34Z",
      "content_text": "BMJ (Clinical research ed.). No need to modify contraceptive counseling or screening for colorectal cancer based on hormonal contraceptive use in premenopausal women, as modern formulations show no clear protective or harmful effect."
    },
    {
      "id": "https://siftingsignal.com/gisignals/2026-W29/#card-pmid-42461618",
      "url": "https://siftingsignal.com/gisignals/2026-W29/#card-pmid-42461618",
      "title": "Three-Year Follow-Up of the Randomized Trial Comparing Open Versus Laparoscopic Surgery for Primary Tumor Resection in Patients With Non-Curable Stage IV Colon Cancer (JCOG1107).",
      "date_published": "2026-07-18T20:04:34Z",
      "content_text": "Diseases of the colon and rectum. Consider laparoscopic surgery as an acceptable option for symptomatic, non-curable stage IV colon cancer (cecum to rectosigmoid, with stenosis/bleeding and 1-3 non-curable factors), given non-inferiority to open surgery in progression-free survival. Postoperative chemotherapy options include modified FOLFOX6 plus bevacizumab or capecitabine plus oxaliplatin with bevacizumab."
    },
    {
      "id": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42379137",
      "url": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42379137",
      "title": "Inter and intra-observer agreement for the LST Classification in Large (>2cm) Colorectal Laterally Spreading Tumours.",
      "date_published": "2026-07-09T16:47:07Z",
      "content_text": "The American journal of gastroenterology. The full LST subtype system has only fair inter-observer reliability (kappa about 0.36) versus moderate (about 0.48) for a simplified granular vs non-granular split, so weight the reproducible split but still document the high-risk nodular-mixed and pseudodepressed features, since guidelines use them to select en-bloc resection or ESD."
    },
    {
      "id": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42379837",
      "url": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42379837",
      "title": "Helicobacter pylori infection, treatment and colorectal cancer risk by genetic predisposition: evidence from two randomised trials.",
      "date_published": "2026-07-09T16:47:07Z",
      "content_text": "Gut. In two eradication trials, H. pylori treatment was linked to lower CRC risk mainly in genetically high-risk or virulence-factor-positive subgroups, an interesting hypothesis but not yet practice: H. pylori is not a CRC-prevention target, and infected patients should still be offered eradication on standard gastric indications regardless of genetic or virulence status."
    },
    {
      "id": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42390126",
      "url": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42390126",
      "title": "ACG Clinical Guideline: Colonic Diverticulitis.",
      "date_published": "2026-07-09T16:47:07Z",
      "content_text": "The American journal of gastroenterology. In immunocompetent patients with mild, CT-confirmed uncomplicated left-sided diverticulitis who are non-toxic (no SIRS, CRP under 140 mg/L, WBC under 15), tolerating oral intake, and safe for outpatient care, manage without antibiotics; reserve antibiotics for immunocompromise, frailty, significant comorbidity, systemic inflammation, or refractory symptoms."
    },
    {
      "id": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42398514",
      "url": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42398514",
      "title": "Bowel endometriosis: from pathogenesis to clinical management.",
      "date_published": "2026-07-09T16:47:07Z",
      "content_text": "The lancet. Gastroenterology & hepatology. For women with severe pelvic/GI symptoms and suspected endometriosis (e.g., dysmenorrhea, dyspareunia), evaluate for rectosigmoid endometriosis via transvaginal ultrasound or MRI. First-line hormonal therapy (OCPs/progestogens) may help symptoms; surgery only for confirmed obstruction/severe refractory cases."
    },
    {
      "id": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42400343",
      "url": "https://siftingsignal.com/gisignals/2026-W26/#card-pmid-42400343",
      "title": "Competing Mortality Redefines the Net Benefit of Additional Surgery After Endoscopic Resection for T1 Colorectal Cancer in Older Adults.",
      "date_published": "2026-07-09T16:47:07Z",
      "content_text": "Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society. For older adults (≥80y) with high-risk T1 CRC, weigh delayed oncologic benefit (10+ years) against immediate surgical risks; consider pathologic risk, frailty, comorbidity, and competing mortality. Avoid routine additional surgery in frail or comorbid patients."
    }
  ]
}